PCNA is a homopolymer complex (trimer) of 34 kD. This auxiliary protein of DNA polymerase δ plays a key role in the regulation of DNA replication and repair. PCNA is also important in cell cycle regulation.
The presence of PCNA antibodies is highly specific of Systemic Lupus Erythematosus (SLE) but rarely found as it represents less than 5% of patients. These autoantibodies are generally associated with renal involvement, Central Nervous System (CNS) manifestations and Thrombocytopenia.
Antigen used by D-tek
Recombinant, human, expressed in Baculovirus-infected Sf9 cells (for more information on our antigens click here)