Anti-ß2-GPI antibodies can be of the IgA, IgG or IgM isotype. IgA are reported as to be most prevalent. IgG and IgM are diagnostic markers and classification criteria of Antiphospholipid Syndrome (APS). Anti-ß2-GPI antibodies are reported to be more specific but less sensitive than anti-cardiolipin antibodies for APS.

APS presents variable clinical features such as venous and arterial thrombosis, recurrent spontaneous abortions and neurological complications. APS may occur as an isolated disease entity (formerly primary APS) or in combination with another autoimmune disease, especially Systemic Lupus Erythematosus (SLE) (formerly secondary APS).


Antigen used by D-tek

Purified from human plasma (for more information on our antigens click here)