Centromere antibodies, also called Anti-Centromere Antibodies (ACA), are directed against Centromere-associated Proteins (CENP) and mainly two polypeptides designated CENP-A (19 kD) and CENP-B (80 kD).
CENP-B is the most common target of ACA (> 95 %) in patients with systemic sclerosis or Raynaud’s phenomenon.
The combined detection of CENP-A and CENP-B antibodies is highly specific for systemic sclerosis (diagnostic specificity up to 99 %). With the determination of CENP-A and CENP-B antibodies nearly all of the systemic sclerosis relevant anti-centromere antibody reactivities as seen by indirect immunofluorescnce on HEp-2 cells can be detected.
Recombinant, human, expressed in Baculovirus infected Sf9 cells (for more information on our antigens click here)