Histone proteins (H1, H2A, H2B, H3 and H4) are in close contact with dsDNA. The complexes histones-dsDNA are called Nucleosome.

Although Anti-histone antibodies (AHA) are generally present in patients with anti-dsDNA antibodies, they are not specific for Systemic Lupus Erythematosus (SLE) but can be detected in a number of autoimmune, infectious or drug-induced diseases. Interestingly, high titers of AHA in the absence of SLE markers antibodies are characteristic of Drug Induced Lupus (DIL).

DIL is a lupus-like syndrome temporally related to continuous drug exposure which resolves after discontinuation of the drug. DIL can notably be caused by procainamide, hydralazine and quinidine.


Antigen used by D-tek

Purified from bovine thymus (for more information on our antigens click here)