DFS-70

Description

Anti-nuclear antibodies (ANA) are a serological hallmark in the diagnosis of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence assay (IFA) using HEp-2 cells, is a commonly employed test for the detection of ANA.

However, up to 20% of apparently healthy individuals have been reported to have a positive ANA-IFA test, primarily related to autoantibodies that target the dense fine speckles 70 (DFS-70) antigen.

Even more important, the DFS-70 IFA pattern has been reported in more than 30% of ANA-IFA positive healthy individuals, but not in ANA-IFA positive SARD patients. Recent studies confirmed that SARD is unlikely in patients where anti-DFS-70 antibodies are found alone.

 

Antigen used by D-tek

Recombinant, human, full length, expressed in E.coli (for more information on our antigens click here)