The Anti-Neutrophil Cytoplasmic Antibodies (ANCA) are a group of autoantibodies directed against cytoplasmic components of the neutrophilic granulocytes. They have been classified into cytoplasmic (c-ANCA) and perinuclear (p-ANCA) according to the indirect immunofluorescence pattern they give on ethanol-fixed human neutrophils and are useful serological markers for vasculitides.

Most c-ANCA antibodies recognize PR3 antigen which is a diagnostic marker Wegener’s Granulomatosis (WG)


Antigen used by D-tek

Purified from human neutrophils (for more information on our antigens click here)