f-Actin antibodies are the main component of the broad family of Smooth Muscle Antibodies (SMA). They bind to the f-Actin component, a globular protein of 41kDa polymerized into filaments, in the cytoskeleton of the cells.
f-Actin in its biologically active polymerized form is the most specific and sensitive autoantigen of Autoimmune Hepatitis type 1. A correct interpreted f-Actin pattern on SMA is reported to have a sensitivity of ~90 % and a specificity of ~100 % for patients with acute phase of Autoimmune Hepatitis type 1.
Prepared from purified G-actin (rabbit skeletal muscle) (for more information on our antigens click here)