Anti-gp210 antibodies are highly specific of Primary Biliary Cirrhosis (PBC).

The main diagnostic marker for PBC is Anti-Mitochondrial antibodies (AMA). However, 5 to 10 % of PBC patients do not present AMA. Some of these patients present PBC specific antinuclear antibodies such as antibodies to nuclear dots (sp100), antibodies to nuclear membrane (gp210) and antibodies to centromeres

Anti-gp210 antibodies are also reported to be associated with extra-hepatic manifestations such as arthritis.


Antigen used by D-tek

36-amino acid sequence corresponding to the C-terminal cytoplasmic tail of gp210, human, recombinant, expressed in E.coli (for more information on our antigens click here)