Anti-Fibrillarin (or anti-U3-SnRNP) antibody occurs in ANA-Hep2 as a clumpy nucleolar pattern. This antibody stains both the nucleoli and the coilin bodies, which is consistent with the known distribution of the U3-Sn RNP particle. Condensed chromatin in mitotic cells is also stained (fibrillar, lace-like staining).
The autoantibodies recognize a highly conserved 34 kDa basic protein of small nucleolar ribonucleoprotein particles.
Although this antibody occurs less frequently than other major SSC-specific autoantibodies, it is considered specific for SSc and mostly related to young SSc patients with frequent organ involvement, especially pulmonary hypertension, myositis and renal involvement.
Recombinant, human, expressed in E.coli (for more information on our antigens click here)