Anti-Fibrillarin (or anti-U3-SnRNP) antibody occurs in ANA-Hep2 as a clumpy nucleolar pattern. This antibody stains both the nucleoli and the coilin bodies, which is consistent with the known distribution of the U3-Sn RNP particle. Condensed chromatin in mitotic cells is also stained (fibrillar, lace-like staining).

The autoantibodies recognize a highly conserved 34 kDa basic protein of small nucleolar ribonucleoprotein particles.

Although this antibody occurs less frequently than other major SSC-specific autoantibodies, it is considered specific for SSc and mostly related to young SSc patients with frequent organ involvement, especially pulmonary hypertension, myositis and renal involvement.


Antigen used by D-tek

Recombinant, human, expressed in E.coli (for more information on our antigens click here)