HMGCR (3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase) antibodies are associated with Idiopathic Inflammatory Necrotizing Myopathies (IINM).

HMGCR is the target of statins which are used to reduce cholesterol levels. Muscle pain and weakness are common side effects of statins treatment but some patients present anti-HMGCR antibodies and IINM. It seems that anti-HMGCR antibodies are not limited to statins patients as they have been also described in statins-unexposed patients.


Antigen used by D-tek

Amino acid sequence 450-888 corresponding to the catalytic domain of HMGCR, human, recombinant, expressed in E.coli